Neuronal Signaling > Research > Sørensen Group
Neuronal Signaling Laboratory
Jakob Balslev Sørensen - Neurosecretion Group
The focus of our interest is the molecular mechanism of neurotransmitter release in central neurons and in neurosecretory cells.
Synaptic vesicles fuse with the plasma membrane to release their content of neurotransmitter. Similarly, neuropeptides and hormones are released through exocytosis of secretory vesicles. We want to understand how exocytosis is executed, which role(s) the presynaptic proteins and lipids play, and how neurotransmitter release is regulated. Finally, we want to understand the link to disease, since aberrant signaling is linked to neuropsychiatric disorders.
We are currently looking for students interested in doing their Master and/or PhD project in our group. We will actively support the application of suitable students for PhD scholarships from various sources. The projects might include both electrophysiological, optical and molecular biology techniques. If you are interested in becoming a member of our team, please contact: Jakob B. Sørensen (email), phone: +45 3532 7931.
Vesicle fuses with the plasma membrane and releases its content of neurotransmitter (shown as a green core). Fusion is triggered by calcium (red dots) influx through calcium channels and is catalyzed by proteins acting in the interface between the vesicle and plasma membrane.
