Ansatte – Københavns Universitet

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Institut for Neurovidenskab og Farmakologi > Ansatte

Kenneth Lindegaard Madsen

Kenneth Lindegaard Madsen

Lektor

My research addresses fundamental aspects of basic pharmacology, molecular pharmacology and neuropharmacology, with certain potential translational parts. The work is divided into three Work Packages each containing a number of specific projects. Work Package 1 is focused on the pharmacology of PSD95/Disc-large/ZO-1 homology (PDZ) mediated proteins-protein interaction and how these domains might represent new attractive pharmacological targets as alternatives to surface receptors. Work Package 2 will seek to explore the controversial idea that trafficking of receptors and transporters, which in many cases is strongly integrated with their pharmacology, is determined not only by protein-protein interactions, but also by yet unappreciated protein-lipid interactions that govern localization of the receptors and transporters to areas of high membrane curvature in the plasma membrane. Work Package 3 is aimed at obtaining fundamental new understanding of dopamine signaling processes in the brain. Evidently, this has broad pharmacotherapeutic perspectives given the key role of dysfunctional dopamine signaling in many brain disease including schizophrenia, bipolar disorder, ADHD, Parkinsons’ Disease and drug abuse.

Primære forskningsområder

Signalling and Scaffolding Processes

Molecular Aspects of Synaptic Plasticity

Addiction

PDZ domains

BAR domains

Protein Lipid Interactions

 

Udvalgte publikationer

  1. Udgivet

    PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    Holst, B., Madsen, K. L., Jansen, A. M., Jin, C., Rickhag, K. M., Lund, V. K., Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, D., Qvortrup, K., Huganir, R., Stamou, D., Kjærulff, O. & Gether, U. apr. 2013 I : P L o S Biology (Online). 11, 4, s. 1-25 25 s., e1001542

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  2. Udgivet

    Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD

    Thorsen, T. S., Madsen, K. L., Rebola, N., Rathje, M., Anggono, V., Bach, A., Moreira, I. S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, K., Rønn, L. C. B. & Gether, U. 2010 I : Proceedings of the National Academy of Science of the United States of America. 107, 1, s. 413-8 5 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  3. Udgivet

    How curved membranes recruit amphipathic helices and protein anchoring motifs

    Hatzakis, N., Bhatia, V. K., Larsen, J., Madsen, K. L., Bolinger, P-Y., Kunding, A. H., Castillo Leon, J. J., Gether, U., Hedegård, P. & Stamou, D. 2009 I : Nature Chemical Biology. 5, 11, s. 835-841 6 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

  4. Udgivet

    Amphipathic motifs in BAR domains are essential for membrane curvature sensing

    Bhatia, V. K., Madsen, K. L., Bolinger, P-Y., Kunding, A., Hedegård, P., Gether, U. & Stamou, D. 2009 I : EMBO Journal. 28, 21, s. 3303-3314 11 s.

    Publikation: Forskning - fagfællebedømtTidsskriftartikel

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